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Reprogramming to recover youthful epigenetic information and restore vision

Yuancheng Ryan Lu, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L. Vera, Qiurui Zeng, Doudou Yu, Michael S. Bonkowski, Jae-Hyun Yang, Songlin Zhou, Emma Hoffmann, Margarete M. Karg, Michael Schultz, Alice E. Kane, Noah Davidsohn, Ekaterina Korobkina, Karolina Chwalek, Luis A. Rajman, George M. Church, Konrad Hochedlinger, Vadim N. Gladyshev, Steve Horvath, Morgan E. Levine, Meredith Gregory‐Ksander, Bruce R. Ksander, Zhigang He, David Sinclair

2020Nature832 citationsDOIOpen Access PDF

Topics & Concepts

ReprogrammingBiologyDNA methylationEpigeneticsSOX2Regeneration (biology)Cell biologyTranscriptomeNeuroscienceGeneticsGene expressionGeneTranscription factorNeurogenesis and neuroplasticity mechanismsPluripotent Stem Cells ResearchRetinal Development and Disorders
Reprogramming to recover youthful epigenetic information and restore vision | Litcius