Synthesis and Application of Novel Magnetic Glycoluril Tetrakis(Methylene Phosphorous Acid) as a Nano Biological Catalyst for the Preparation of Nicotinonitriles <i>via</i> a Cooperative Vinylogous Anomeric-Based Oxidation
Bashirullah Danishyar, Hassan Sepehrmansourie, Mahmoud Zarei, Mohammad Ali Zolfigol, Mohammad Ali As’habi, Yanlong Gu
Abstract
Herein, we synthesized biological magnetic glycoluril tetrakis(methylene phosphorous acid) as a new heterogeneous nano-catalyst. The magnetic nano-catalyst Fe3O4@GTMPA was used for the synthesis of diphenyl nicotinonitrile derivatives by multi-component reaction of wide spread aldehydes, acetophenones, ammonium acetate, and 3-(1H-indol-3-yl)-3-oxopropanenitrile in the solvent-free conditions at 110 °C. The final step of reaction mechanism was preceded via a cooperative vinylogous anomeric-based oxidation (CVABO) as green and convenient approach.
Topics & Concepts
ChemistryCatalysisMethyleneNano-Ammonium acetateAnomerSolventOrganic chemistryReaction conditionsCombinatorial chemistryChemical engineeringHigh-performance liquid chromatographyEngineeringChemical Synthesis and ReactionsSynthesis of Indole DerivativesMulticomponent Synthesis of Heterocycles