Selective Binding of Bovine Serum Albumin (BSA): A Comprehensive Review
Unknown authors
Abstract
Numerous complexes have been synthesized and characterized as the result of the ongoing search for novel molecules with potent therapeutic properties. These compounds have been shown to have potential applications as pharmacological agents due to their antibacterial, antiviral, antifungal, anticancer, and antineoplastic properties. The study of the coordination compound’s affinity for this family of proteins as well as a knowledge of the mechanism by which they interact is essential due to the significant role that serum albumin plays in the pharmacokinetics and pharmacodynamics of medications. This review will concentrate on the composition of Schiff base, Schiff base metal complexes, various drug derivatives, nanoparticles, quinoline derivatives, and imidazolium-based salt derivatives that can bind to bovine serum albumin (BSA), its structural and biological rules, as well as various experimental techniques like UV-Vis absorption, Fluorescence, Dynamic light scattering (DLS), Circular dichroism (CD) and computational methods like molecular docking studies are used to investigate and assess these interactions.