Design, synthesis, and antitumor evaluation of quinazoline-4-tetrahydroquinoline chemotypes as novel tubulin polymerization inhibitors targeting the colchicine site
Qinhuai Lai, Zhijia Wang, Chengyong Wu, Ruofei Zhang, Leyan Li, Yiran Tao, Dan Mo, Jifa Zhang, Lantu Gou, Yuxi Wang, Lantu Gou, Yuxi Wang
Topics & Concepts
ChemistryColchicineTubulinChemotypeQuinazolineCombinatorial chemistryStereochemistryMicrotubuleInternal medicineBiologyChromatographyMedicineEssential oilCell biologyQuinazolinone synthesis and applicationsSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds