Gut Microbiota of Obese Children Influences Inflammatory Mucosal Immune Pathways in the Respiratory Tract to Influenza Virus Infection: Optimization of an Ideal Duration of Microbial Colonization in a Gnotobiotic Pig Model
Sankar Renu, Löıc Deblais, Veerupaxagouda Patil, Jennifer Schrock, Dipak Kathayat, Vishal Srivastava, Ninoshkaly Feliciano-Ruiz, Yi Han, A. Ramesh, Yashavanth Shaan Lakshmanappa, Shristi Ghimire, Santosh Dhakal, Gireesh Rajashekara, Gourapura J. Renukaradhya
Abstract
The diversity of gut microbiome of obese people differs markedly from that of lean healthy individuals which, in turn, influences the severity of inflammatory diseases because of differential maturation of immune system. The mouse model provides crucial insights into the mechanism(s) regulating the immune systems mediated by the gut microbiota but its applicability to humans is questionable because immune cells in mice are poorly activated in microbiota humanized mice. Several important strains of Bifidobacterium , Lactobacillus , and Clostridium fails to colonize the murine gut.