Müller glia-derived exosomal miR-9-3p promotes angiogenesis by restricting sphingosine-1-phosphate receptor S1P1 in diabetic retinopathy
Yu Liu, Qin Yang, Haixin Fu, Jingfan Wang, Songtao Yuan, Xinsheng Li, Ping Xie, Zizhong Hu, Qinghuai Liu
Abstract
coding sequence, which subsequently activated VEGFR2 phosphorylation and internalization in the presence or absence of exogenous VEGF-A. We successfully orchestrated the dynamic crosstalk between retinal Müller glia cells and endothelial cells in pathological condition, which may provide a novel biomarker or promising therapeutic agents for the treatment of diabetic retinopathy.
Topics & Concepts
Sphingosine-1-phosphateAngiogenesisDiabetic retinopathySphingosineReceptorSphingosine-1-phosphate receptorChemistryCell biologyInternal medicineCancer researchEndocrinologyMedicineBiologyDiabetes mellitusExtracellular vesicles in diseaseMicroRNA in disease regulationRetinal Diseases and Treatments