The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity
Jiazheng Zhao, Ning Zhang, Xiaowei Ma, Ming Li, Helin Feng
Abstract
In conjunction with previous studies, we have noted that ferroptosis, as an emerging mode of regulated cell death (RCD), is intimately related to anthracycline pharmacotherapy. Not only does ferroptosis significantly modulate tumour resistance and drug toxicity, which are core links of the relevant chemotherapeutic process, but it also appears to play a conflicting role that has yet to be appreciated. By targeting the dual role of ferroptosis in anthracycline-based chemotherapy, this review aims to focus on the latest findings at this stage, identify the potential associations and provide novel perspectives for subsequent research directions and therapeutic strategies.
Topics & Concepts
AnthracyclineToxicityDual roleDrug resistanceChemotherapyChemotherapeutic drugsResistance (ecology)Drug toxicityMedicinePharmacologyBiologyInternal medicineChemistryCancerBreast cancerMicrobiologyCombinatorial chemistryEcologyFerroptosis and cancer prognosisDrug Transport and Resistance MechanismsCancer, Lipids, and Metabolism