A Nanobody-Mediated Virus-Targeting Drug Delivery Platform for the Central Nervous System Viral Disease Therapy
Song Zhu, Fei Luo, Bin Zhu, Fei Ling, Er-Long Wang, Tian-Qiang Liu, Gao-Xue Wang
Abstract
CNS viral diseases have resulted in many deadly epidemics throughout history and continue to pose one of the greatest threats to public health. Drug therapy remains challenging due to the complex structure and relative impermeability of the biological tissues and barriers. Therefore, development in the intelligent drug delivery platform is highly desired for CNS viral disease therapy. In the study, a nanobody-mediated virus-targeting drug delivery platform is constructed to explore the potential application of targeted therapy in CNS viral diseases. Our findings hold great promise for the application of targeted drug delivery in CNS viral disease therapy.
Topics & Concepts
AmantadineDrug deliveryCentral nervous systemMedicineDiseaseDrugViral vectorVirologyVirusAntiviral drugViral loadImmunologyPharmacologyViral encephalitisEncephalopathyViral diseaseDrug discoveryPharmacotherapyTargeted drug deliveryBioinformaticsTropical diseaseDemyelinating diseaseNervous systemVirus-based gene therapy researchPolyomavirus and related diseasesRNA Interference and Gene Delivery