Design, synthesis,<i>in silico</i>molecular modelling studies and biological evaluation of novel indole-thiazolidinedione hybrid analogues as potential pancreatic lipase inhibitors
Ginson George, Prashant S. Auti, Atish T. Paul
Abstract
A series of thiazolidinedione-indole hybrids are designed and synthesized as a potential inhibitor for pancreatic lipase (PL).
Topics & Concepts
ChemistryIn silicoIndole testThiazolidinedioneLipasePancreatic lipaseCombinatorial chemistryBiochemistryComputational biologyEnzymeStereochemistryGeneEndocrinologyMedicineBiologyType 2 diabetesDiabetes mellitusEnzyme Catalysis and ImmobilizationComputational Drug Discovery MethodsPharmacology and Obesity Treatment