Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?
Daniela Ligi, Rosanna Maniscalco, Mario Plebani, Giuseppe Lippi, Ferdinando Mannello
Abstract
Several studies shed light on the interplay among inflammation, thrombosis, multi-organ failures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Increasing levels of both free and/or circulating histones have been associated to coronavirus disease 2019 (COVID-19), enhancing the risk of heart attack and stroke with coagulopathy and systemic hyperinflammation. In this view, by considering both the biological and clinical rationale, circulating histones may be relevant as diagnostic biomarkers for stratifying COVID-19 patients at higher risk for viral sepsis, and as predictive laboratory medicine tool for targeted therapies.
Topics & Concepts
MedicineCoagulopathySepsisSystemic inflammatory response syndromeSystemic inflammationDisseminated intravascular coagulationConsumptive CoagulopathyImmunologyThrombosisInflammationIntensive care medicineInternal medicineNeutrophil, Myeloperoxidase and Oxidative MechanismsCOVID-19 Clinical Research StudiesAtherosclerosis and Cardiovascular Diseases