Cross-sectional associations of CSF tau levels with Rey’s AVLT: A recency ratio study.
Davide Bruno, Ainara Jauregi Zinkunegi, Nunzio Pomara, Henrik Zetterberg, Kaj Blennow, Rebecca L. Koscik, Cynthia M. Carlsson, Barbara B. Bendlin, Ozioma C. Okonkwo, Bruce P. Hermann, Sterling C. Johnson, Kimberly D. Mueller
Abstract
OBJECTIVE: The preeminent in vivo cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are amyloid β 1-42 (Aβ42), phosphorylated Tau (p-tau), and total Tau (t-tau). The goal of this study was to examine how well traditional (total and delayed recall) and process-based (recency ratio [Rr]) measures derived from Rey's Auditory Verbal Learning test (AVLT) were associated with these biomarkers. METHOD: = 6.9), who ranged from cognitively unimpaired to mild cognitive impairment, and for whom CSF values were available, were extracted from the Wisconsin Registry for Alzheimer's Prevention. Bayesian regression analyses were carried out using CSF scores as outcomes, AVLT scores as predictors, and controlling for demographic data and diagnosis. RESULTS: = 3.57). CONCLUSIONS: Our findings suggest that Rr may be a better cognitive measure than commonly used AVLT scores to assess CSF levels of p-tau and t-tau in nondemented individuals. (PsycInfo Database Record (c) 2023 APA, all rights reserved).