Expression of claudin-8 is induced by aldosterone in renal collecting duct principal cells
Ali Sassi, Yubao Wang, Alexandra Chassot, Isabelle Roth, Suresh Krishna Ramakrishnan, Valérie Olivier, Olivier Staub, Khalil Udwan, Eric Féraille
Abstract
In this study, we showed that aldosterone modulates claudin-8 expression in cultured collecting duct principal cells and in the mouse kidney. The upregulation of claudin-8 expression in response to aldosterone is dependent on at least glycogen synthase kinase-3, Lyn, and Abl signaling pathways, indicating the participation of multiple protein kinases to the effect of aldosterone.
Topics & Concepts
AldosteroneParacellular transportEndocrinologyReabsorptionInternal medicineMineralocorticoid receptorClaudinEpithelial sodium channelChemistryRenal sodium reabsorptionMineralocorticoidTight junctionBiologyKidneyCell biologyPermeability (electromagnetism)SodiumMedicineBiochemistryOrganic chemistryMembraneIon Transport and Channel RegulationBarrier Structure and Function StudiesDiet and metabolism studies