Application prospect of calcium peroxide nanoparticles in biomedical field
Xincai Wu, Han Xu, Yang Guo, Qian Liu, Ran Sun, Zhaohui Wen, Changsong Dai
Abstract
Abstract In recent years, calcium peroxide (CaO 2 ) has attracted widespread attention in the medical community due to its excellent antitumor and antibacterial properties, and has gradually become a hot research topic in the biomedical field. CaO 2 reacts with water (H 2 O) to produce calcium ion (Ca 2+ ), oxygen (O 2 ), and hydrogen peroxide (H 2 O 2 ), where Ca 2+ is suitable for calcium death caused by calcium overload, O 2 is suitable for O 2 -dependent anticancer therapy, and H 2 O 2 is suitable for H 2 O 2 -dependent anticancer therapy. In addition, H 2 O 2 can also be used in the antibacterial field to treat bacterial infections. All these make the CaO 2 to become a kind of excellent antitumor and antibacterial drug. This study mainly reviews the preparation and surface modification of CaO 2 , probes into the latest progress about CaO 2 nanoparticles in the field of tumor treatment and antimicrobial therapy. Finally, the challenges that CaO 2 still faces in the future research field are clarified, and its prospects are forecasted.