Improving and measuring the solubility of favipiravir and montelukast in SC-CO<sub>2</sub> with ethanol projecting their nanonization
Adrián Rojas, Seyed Ali Sajadian, Carol López-de-Dicastillo, Nedasadat Saadati Ardestani, Gonzalo Águila, Abolghasem Jouyban
Abstract
. The highest values were achieved in the pressure of 12 MPa and temperature of 338 K. Last but not least, six density-based semi-empirical models with various adjustable parameters were used to perform the modeling of the solubility of favipiravir and montelukast.
Topics & Concepts
MontelukastSolubilityEthanolFavipiravirChemistryMedicinal chemistryOrganic chemistryInternal medicineMedicineDiseaseInfectious disease (medical specialty)Coronavirus disease 2019 (COVID-19)AsthmaAnalytical Chemistry and ChromatographyProtein purification and stabilityCrystallization and Solubility Studies