Enantioselective Inverse-Electron Demand Aza-Diels–Alder Reaction: ipso,α-Selectivity of Silyl Dienol Ethers
Víctor Laina‐Martín, Jorge Humbrías‐Martín, Rubén Mas‐Ballesté, José A. Fernández‐Salas, José Alemán
Abstract
isomer of the dienol ether. Furthermore, to demonstrate the applicability of silyl enol ethers as nucleophiles in the asymmetric synthesis of interesting benzofuran-fused derivatives, the catalytic system has also been implemented for the highly efficient installation of an aromatic ring in the piperidine adducts.
Topics & Concepts
Enantioselective synthesisChemistrySilyl enol etherSilylationStereocenterOxonium ionEnolNucleophileDiels–Alder reactionOrganic chemistryCatalysisIonAsymmetric Synthesis and CatalysisCyclopropane Reaction MechanismsOxidative Organic Chemistry Reactions