Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement
Helen K. Matthews, Sushila Ganguli, Katarzyna Plak, Anna Taubenberger, Zaw Win, Max Williamson, Matthieu Piel, Jochen Guck, Buzz Baum
Abstract
enables cells to proliferate under conditions of mechanical confinement like those experienced by cells in crowded tumors.
Topics & Concepts
BiologyCell biologyCellCell divisionCell mechanicsSignal transductionDivision (mathematics)GeneticsCytoskeletonMathematicsArithmeticCellular Mechanics and InteractionsHippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamics