Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense
P. Hima Kumari, Ashley J. Russo, Skylar S. Wright, Sureshkumar Muthupalani, Vijay Rathinam
Abstract
cells and IECs, is necessary for bacterial clearance and host survival during intracellular bacterial infection. Thus, we reveal hierarchical cell-type-specific roles of caspase-11 that govern the host-protective and host-detrimental functions of the cytosolic LPS surveillance.
Topics & Concepts
Host (biology)Cell biologyShock (circulatory)MicrobiologyChemistryBiologyImmunologyGeneticsMedicineInternal medicineInflammasome and immune disordersCell death mechanisms and regulationImmune Response and Inflammation