Self-delivery nanomedicine for chemotherapy sensitized photodynamic therapy
Lingshan Liu, Xiang Zhou, Rongrong Zheng, Jiaqi Huang, Renjiang Kong, Yanmei Li, Chang Wang, Ali Chen, Shiying Li, Hong Cheng
Abstract
A chlorine e6 (Ce6) and curcumin (Cur) based self-delivery nanomedicine (CeCu) is prepared for chemotherapy sensitized photodynamic therapy (PDT). The chemotherapeutic agent of Cur could inhibit the TrxR activity to destroy the cellular ROS-defence system for enhanced PDT, which provides synergistic effects for tumor precision therapy in consideration of the unfavorable tumor microenvironments.
Topics & Concepts
Photodynamic therapyNanomedicineMedicineDrug deliveryNanotechnologyMaterials scienceChemistryNanoparticleOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Nanomaterials in Catalysis