Rhoda‐Electrocatalyzed Bimetallic C−H Oxygenation by Weak <i>O</i>‐Coordination
Xuefeng Tan, Leonardo Massignan, Xiaoyan Hou, Johanna Frey, João C. A. Oliveira, Masoom Nasiha Hussain, Lutz Ackermann
Abstract
Rhodium-electrocatalyzed arene C-H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C-H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C-H activation by a bimetallic rhodium catalysis manifold.
Topics & Concepts
Bimetallic stripOxygenationChemistryMedicineInternal medicineCatalysisBiochemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsOxidative Organic Chemistry Reactions