Limitations to exercise tolerance in type 1 diabetes: the role of pulmonary oxygen uptake kinetics and priming exercise
Richie P. Goulding, Denise M. Roche, Sam N. Scott, Shunsaku Koga, Philip J. Weston, Simon Marwood
Abstract
Patients with type 1 diabetes demonstrated slower oxygen uptake (V̇o 2 ) kinetics compared with healthy control subjects. Furthermore, a prior bout of high-intensity exercise speeded V̇o 2 kinetics and increased critical power in people with type 1 diabetes. Prior exercise speeded muscle deoxygenation kinetics, indicating that V̇o 2 kinetics in type 1 diabetes are limited primarily by oxygen extraction and/or intracellular factors. These findings highlight the potential for interventions that decrease metabolic inertia for enhancing exercise tolerance in this condition.
Topics & Concepts
KineticsDeoxygenationInternal medicinePriming (agriculture)Diabetes mellitusType 2 diabetesPhysical exerciseType 1 diabetesMedicineVentilatory thresholdChemistryVO2 maxEndocrinologyBiochemistryBiologyHeart rateQuantum mechanicsPhysicsGerminationCatalysisBotanyBlood pressureCardiovascular and exercise physiologyHeart Rate Variability and Autonomic ControlPhysical Activity and Health