Activity-Based NIR Bioluminescence Probe Enables Discovery of Diet-Induced Modulation of the Tumor Microenvironment via Nitric Oxide
Anuj K. Yadav, Michael Lee, Melissa Y. Lucero, Shengzhang Su, Christopher J. Reinhardt, Jefferson Chan
Abstract
-NO provides the first direct molecular evidence that intratumoral NO becomes elevated in mice fed a high-fat diet, which became obese with larger tumors, compared to control animals on a low-fat diet. These results indicate that an inflammatory diet can increase NO production via recruitment of macrophages and overexpression of inducible nitric oxide synthase which in turn can drive tumor progression.
Topics & Concepts
Bioluminescence imagingNitric oxideTumor microenvironmentContext (archaeology)CancerMetastasisIn vivoInflammationBioluminescenceImmune systemChemistryCancer cellCancer researchCytotoxic T cellTumor progressionBiologyMedicineImmunologyBiochemistryIn vitroInternal medicineLuciferaseBiotechnologyGeneTransfectionPaleontologyNitric Oxide and Endothelin EffectsNanoplatforms for cancer theranosticsCancer, Stress, Anesthesia, and Immune Response