microRNA 1307 Is a Potential Target for SARS-CoV-2 Infection: An <i>in Vitro</i> Model
Elif Damla Arısan, D. Alwyn Dart, Guy H. Grant, Andrew Dalby, Derya Dilek Kançağı, Raife Dilek Turan, Bulut Yurtsever, Gözde Sır Karakuş, Ercüment Ovalı, Sigrun Lange, Pinar Uysal‐Onganer
Abstract
analysis that miR-1307-3p is conserved in all SARS-CoV-2 sequences/strains, except in the BA.2 variant, possibly contributing to the lower disease severity of this variant, which warrants further investigation. Small RNA seq analysis was next used to evaluate alterations in the miRNOME, following miR-1307-3p manipulation, identifying critical pathobiological pathways linked to SARS-CoV-2 infection-mediated upregulation of this miR. On the basis of our findings, miRNAs like miR-1307-3p play a critical role in SARS-CoV-2 infection, including via effects on disease progression and severity.