Adaptive changes in single-nephron GFR, tubular morphology, and transport in a pregnant rat nephron: modeling and analysis
Melissa M. Stadt, Anita T. Layton
Abstract
Normal pregnancy in mammals is generally characterized by massive changes in plasma volume and electrolyte retention. This study provides insights into how the volume and electrolyte requirement in different pregnancy stages are met by coordinated adaptive changes in the kidney. The model results also suggested that certain known sex differences in the renal transporter pattern may serve to better prepare females for the increased transport demand in pregnancy.
Topics & Concepts
NephronReabsorptionEndocrinologyInternal medicinePregnancyKidneyRenal physiologyElectrolyteHomeostasisPlacentaChemistryFetusTonicityBiologyMedicineGeneticsPhysical chemistryElectrodeElectrolyte and hormonal disordersIon Transport and Channel RegulationPregnancy and preeclampsia studies