Site-Selective Electrochemical C–H Cyanation of Indoles
Laiqiang Li, Zhong‐Wei Hou, Pinhua Li, Lei Wang
Abstract
An electrochemical approach for the site-selective C-H cyanation of indoles employing readily available TMSCN as cyano source has been developed. The electrosynthesis relies on the tris(4-bromophenyl)amine as a redox catalyst, which achieves better yield and regioselectivity. A variety of C2- and C3-cyanated indoles were obtained in satisfactory yields. The reactions are conducted in a simple undivided cell at room temperature and obviate the need for transition-metal reagent and chemical oxidant.
Topics & Concepts
CyanationChemistryElectrosynthesisRegioselectivityReagentYield (engineering)Combinatorial chemistryElectrochemistryAmine gas treatingCatalysisRedoxOrganic chemistryElectrodeMetallurgyPhysical chemistryMaterials scienceCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsOxidative Organic Chemistry Reactions