Defining human mean circulatory filling pressure in the intensive care unit
Marije Wijnberge, Jaap Schuurmans, Rob B. P. de Wilde, Martijn Kerstens, Alexander P. J. Vlaar, Markus W. Hollmann, Denise P. Veelo, Michael R. Pinsky, Jos R. C. Jansen, Bart F. Geerts
Abstract
In a cohort of 311 intensive care unit (ICU) patients, median mean circulatory filling pressure (Pmcf) measured after cardiac arrest was 15 mmHg (interquartile range 12-18). In 48% of cases, arterial blood pressure remained higher than central venous pressure, but correction for arterial-to-venous compliance differences did not result in clinically relevant alterations of Pmcf. Fluid balance, use of vasopressors or inotropes, and being on mechanical ventilation were associated with a higher Pmcf.
Topics & Concepts
Circulatory systemIntensive care unitMean circulatory filling pressureBlood pressureMedicineCardiologyAnesthesiaIntensive care medicineInternal medicineCentral venous pressureHeart rateHemodynamic Monitoring and TherapyNon-Invasive Vital Sign MonitoringCardiac, Anesthesia and Surgical Outcomes