Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5′-monophosphate decarboxylase catalysis
Sören Rindfleisch, Matthias Krüll, Jon Uranga, Tobias Schmidt, Fabian Rabe von Pappenheim, Laura Liliana Kirck, Angeliki Balouri, T. Schneider, Ashwin Chari, Ronald Kluger, Gleb Bourenkov, Ulf Diederichsen, Ricardo A. Mata, Kai Tittmann
Topics & Concepts
Active siteChemistryTransition state analogSubstrate (aquarium)Enzyme catalysisProtonationCarboxylateCatalysisTransition stateStereochemistryLeaving groupCatalytic cycleHydrogen bondReaction coordinatePhotochemistryComputational chemistryOrganic chemistryMoleculeIonOceanographyGeologyEnzyme Structure and FunctionNeurological diseases and metabolismPorphyrin Metabolism and Disorders