DLX5 promotes osteosarcoma progression via activation of the NOTCH signaling pathway.
Xiaojing Zhang, Huiqin Bian, Wei Wei, Qian Wang, Jinnan Chen, Ruoxuan Hei, Chen Chen, Xuan Wu, Haochun Yuan, Junxia Gu, Yaojuan Lu, Cheguo Cai, Qiping Zheng
Abstract
promoter. Dual-luciferase assay demonstrated that DLX5 specifically activates the NOTCH1 promoter and controls its expression. Taken together, our results support that DLX5 plays an oncogenic role in OS development, which can at least partially, be attributed to activation of the NOTCH signaling pathway.
Topics & Concepts
DLX5OsteoblastRUNX2OsteosarcomaCell growthCancer researchTranscription factorGene knockdownCell cultureBiologyCell biologyHomeoboxIn vitroGeneBiochemistryGeneticsCancer-related gene regulationCancer-related molecular mechanisms researchRNA modifications and cancer