CarRS Two-Component System Essential for Polymyxin B Resistance of Vibrio vulnificus Responds to Multiple Host Environmental Signals
Duhyun Ko, Dayoung Sung, Tae Young Kim, Garam Choi, Ye‐Ji Bang, Sang Ho Choi
Abstract
operons regardless of phosphorylation, phosphorylation of CarR is required for the regulation of the operons, resulting in the PMB resistance. Furthermore, the CarRS TCS determines the resistance of V. vulnificus to bile salts and acidic pH by differentially regulating its own activation state in response to these environmental stresses. Altogether, the CarRS TCS responds to multiple host-related signals, and thus could enhance the survival of V. vulnificus within the host, leading to successful infection.
Topics & Concepts
Vibrio vulnificusComponent (thermodynamics)Host (biology)MicrobiologyVibrio InfectionsPolymyxinBiologyPolymyxin BVibrioBacteriaEcologyAntibioticsGeneticsPhysicsThermodynamicsVibrio bacteria research studiesAquaculture disease management and microbiotaLipid Membrane Structure and Behavior