Recent advances on cyclodepsipeptides: biologically active compounds for drug research
Si-Xuan Liu, Si-Yi Ou-Yang, Yong‐Fu Lu, Guo Chun-lin, Si‐Yang Dai, Chang Li, Tianyi Yu, Yue‐Hu Pei
Abstract
Cyclodepsipeptides are a large family of peptide-related natural products consisting of hydroxy and amino acids linked by amide and ester bonds. A number of cyclodepsipeptides have been isolated and characterized from fungi and bacteria. Most of them showed antitumor, antifungal, antiviral, antimalarial, and antitrypanosomal properties. Herein, this review summarizes the recent literatures (2010-2022) on the progress of cyclodepsipeptides from fungi and bacteria except for those of marine origin, in order to enrich our knowledge about their structural features and biological sources.
Topics & Concepts
DrugBiological activityDrug discoveryComputational biologyChemistryBiologyPharmacologyBiochemistryIn vitroMicrobial Natural Products and BiosynthesisPhytochemical compounds biological activitiesBiochemical and Structural Characterization