Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease
Farhan Khan, Ziyad Allehebi, Yahya Shabi, Ian Davis, Jason J. LeBlanc, L. Robbin Lindsay, Todd F. Hatchette
Abstract
The modified 2-tier testing algorithm (MTTT) for Lyme disease (LD) has been approved by the US Food and Drug Administration. In this study, we show that the MTTT detected 28% more cases of early infection compared with the standard 2-tier algorithm while retaining high specificity in a region with a high incidence of LD.
Topics & Concepts
MedicineLyme diseaseImmunoassaySerologyFood and drug administrationAlgorithmIncidence (geometry)ImmunologyInternal medicineAntibodyComputer sciencePharmacologyPhysicsOpticsVector-borne infectious diseasesMosquito-borne diseases and controlInsect and Pesticide Research