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Cas12n nucleases, early evolutionary intermediates of type V CRISPR, comprise a distinct family of miniature genome editors

Weizhong Chen, Jiacheng Ma, Zhaowei Wu, Zhipeng Wang, Hongyuan Zhang, Wenhan Fu, Deng Pan, Shi Jin, Quanjiang Ji

2023Molecular Cell74 citationsDOIOpen Access PDF

Topics & Concepts

CRISPRBiologyNucleaseComputational biologyGenome editingGenomeRNAGeneticsDNACRISPR interferenceGenome engineeringGuide RNATrans-activating crRNAGeneCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsRNA regulation and disease
Cas12n nucleases, early evolutionary intermediates of type V CRISPR, comprise a distinct family of miniature genome editors | Litcius