Efficient synthesis of 2-aryl-2<i>H</i>-indazoles by base-catalyzed benzyl C–H deprotonation and cyclization
Guoqing Jin, Wenxia Gao, Yunbing Zhou, Miaochang Liu, Huayue Wu
Abstract
A straightforward and efficient method for the preparation of 2-aryl-2H-indazoles from ortho-alkyl substituted azoxybenzenes is presented. The reaction proceeds through base-catalyzed benzyl C-H deprotonation and cyclization to afford 2-aryl-2H-indazoles in good yields. This synthetic strategy can be applied to the construction of several fluorescent and bioactive molecules.
Topics & Concepts
DeprotonationArylBase (topology)CatalysisChemistryMedicinal chemistryStereochemistryOrganic chemistryMathematicsAlkylIonMathematical analysisCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCyclopropane Reaction Mechanisms