Exposure to ozone impacted Th1/Th2 imbalance of CD4+ T cells and apoptosis of ASMCs underlying asthmatic progression by activating lncRNA PVT1-miR-15a-5p/miR-29c-3p signaling
Yangyang Wei, B Han, Wenjuan Dai, Shufang Guo, Caiping Zhang, Lixuan Zhao, Yan Gao, Yi Jiang, Xiaomei Kong
Abstract
<0.05). Additionally, PVT1 seemed promising in diagnosis of asthma, with favorable sensitivity (i.e. 0.844) and specificity (i.e. 0.978). Conclusively, lncRNA PVT1-miR-15a-5p/miR-29c-3p-PI3K-Akt-mTOR axis was implicated in ozone-induced asthma development by promoting ASMC proliferation and Th1/Th2 imbalance.
Topics & Concepts
ApoptosisPVT1Signal transductionCancer researchCell biologyImmunologyBiologyDownregulation and upregulationGeneticsLong non-coding RNAGeneAsthma and respiratory diseasesIL-33, ST2, and ILC PathwaysAir Quality and Health Impacts