Intranasal orexin A modulates sympathetic vascular tone: a pilot study in healthy male humans
Moritz Meusel, Joachim G. Voss, Alexander F. Krapalis, Felix Machleidt, Reinhard Vonthein, Manfred Hallschmid, Friedhelm Sayk
Abstract
Our pilot study adds another important part to the complex network of neuroendocrine-sympathetic interaction. Our results demonstrate that intranasal orexin A elicits an excitatory effect on sympathetic vascular tone superordinate to mere baroreflex feedback regulation. This resetting of the baroreflex set point suggests an activation of hypothalamic core centers such as the paraventricular nucleus (PVN). The role of the orexinergic system in the development of neurogenic arterial hypertension warrants further investigations.
Topics & Concepts
BaroreflexOrexinHeart rateMedicineInternal medicineEndocrinologyBlood pressureOrexin-ANeuropeptidePlaceboAnesthesiaPathologyAlternative medicineReceptorSleep and Wakefulness ResearchRegulation of Appetite and ObesityNeuroscience of respiration and sleep