Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities
Chengfeng Bai, Shuangjie Wu, Shengnan Ren, Meiqi Zhu, Guoshun Luo, Hua Xiang
Topics & Concepts
ChemistryEstrogen receptorBenzothiopheneSelective estrogen receptor modulatorRaloxifeneTamoxifenPharmacologyAntagonistCovalent bondDocking (animal)ReceptorPharmacophoreStereochemistryBiochemistryBreast cancerCancerInternal medicineBiologyMedicineThiopheneOrganic chemistryNursingEstrogen and related hormone effectsSynthesis and biological activityClick Chemistry and Applications