Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors
Yu Xu, Xiujuan Zhang, Wenbo Li, Xingrong Wang, Shuai Wang, Xue-Peng Qiao, Shi‐Wu Chen
Topics & Concepts
ChemistryBRD4BromodomainIC50Docking (animal)PotencyLead compoundIndole testDrugCell growthStereochemistryPharmacologyCombinatorial chemistryIn vitroBiochemistryHistoneNursingMedicineGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways