Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury
Rie Fujii, S. Hasegawa, Hiroshi Maekawa, Tsuyoshi Inoue, Kentaro Yoshioka, Rie Uni, Yoichiro Ikeda, Masaomi Nangaku, Reiko Inagi
Abstract
Here, we demonstrated organelle cross-talk between primary cilia and mitochondria of proximal tubular cells in cisplatin-induced acute kidney injury. The primary cilia-mitochondria interaction may open new avenues for the development of novel therapeutic approaches in the treatment of acute kidney injury.
Topics & Concepts
CiliumPrimary (astronomy)CisplatinCell biologyMitochondrionBiologyMedicineInternal medicinePhysicsAstronomyChemotherapyGenetic and Kidney Cyst DiseasesTuberous Sclerosis Complex ResearchCerebrospinal fluid and hydrocephalus