Upregulation of Cyclin B2 (<i>CCNB2</i>) in breast cancer contributes to the development of lymphovascular invasion.
Abrar Aljohani, Michael S. Toss, Khloud A. Elsharawy, Sameer Mirza, Graham Ball, Andrew R. Green, Emad A. Rakha
Abstract
reduced BC cell lines adherence and transmigration across endothelial cell lines. High CCNB2 protein expression was independently associated with LVI positivity in addition to other features of aggressive behaviour, including larger tumour size, higher histological grade, hormonal receptor-negativity, and HER2-positivity, and with shorter survival. We conclude that CCNB2 plays a crucial role in LVI development in BC, implying that CCNB2 could confer a promising therapeutic target to inhibit LVI and reduce metastatic events.
Topics & Concepts
BiologyTranscriptomeCyclin D1CarcinogenesisCancer researchDownregulation and upregulationCell growthGene knockdownBreast cancerCell cycleCancerCell cultureGene expressionGeneGeneticsFerroptosis and cancer prognosisCancer-related gene regulationCancer-related Molecular Pathways