Visible light-driven Giese reaction with alkyl tosylates catalysed by nucleophilic cobalt
Kimihiro Komeyama, Takuya Michiyuki, Yoshikazu Teshima, Itaru Osaka
Abstract
The scope of the Giese reaction is expanded using readily available alkyl tosylates as substrates and nucleophilic cobalt(i) catalysts under visible-light irradiation. The reaction proceeds preferentially with less bulky primary alkyl tosylates. This unique reactivity enables the regio-selective Giese reaction of polyol derivatives.
Topics & Concepts
AlkylCobaltChemistryNucleophileReactivity (psychology)CatalysisPolymer chemistryPhotochemistryMedicinal chemistryOrganic chemistryAlternative medicineMedicinePathologyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques