Stem-Cell Aging and Pathways to Precancer Evolution
Catriona Jamieson, Irving L. Weissman
Abstract
Stem cells can renew themselves without differentiating. Aging, inflammation, and environmental exposures may drive phenotypic changes in tissue stem cells that cause them to become cancer stem cells.
Topics & Concepts
Stem cellMedicinePhenotypeInflammationCancer stem cellStem cell theory of agingCell biologyCancer researchBiologyImmunologyStem cell factorGeneticsProgenitor cellGeneEpigenetics and DNA MethylationFOXO transcription factor regulationCancer Cells and Metastasis