Zebrafish ( <i>Danio rerio</i> ) as a Model for Understanding the Process of Caudal Fin Regeneration
Lina Lebedeva, Beibitgul Zhumabayeva, Tatyana Gebauer, Ilya Kisselev, Zaure Aitasheva
Abstract
, has become a valuable model for the study of regenerative processes and mechanisms. Zebrafish exhibit epimorphic regeneration, in which a nondifferentiated cell mass formed after amputation is able to fully regenerate lost tissue such as limbs, heart muscle, brain, retina, and spinal cord. The process of limb regeneration in zebrafish comprises several stages characterized by the activation of specific signaling pathways and gene expression. We review current research on key factors in limb regeneration using zebrafish as a model.
Topics & Concepts
ZebrafishDanioRegeneration (biology)BiologyBlastemaAnatomyModel organismCell biologyFish finSpinal cordProcess (computing)NeuroscienceGeneGeneticsFish <Actinopterygii>Computer scienceFisheryOperating systemCongenital heart defects researchMicroRNA in disease regulationZebrafish Biomedical Research Applications