Lipopolysaccharide of the Yersinia pseudotuberculosis Complex
Yuriy A. Knirel, Andrey P. Anisimov, Angelina A. Kislichkina, Anna N. Kondakova, Olga V. Bystrova, A. S. Vagaiskaya, Konstantin Shatalin, Alexander S. Shashkov, Svetlana V. Dentovskaya
Abstract
Lipopolysaccharide (LPS), localized in the outer leaflet of the outer membrane, serves as the major surface component of the Gram-negative bacterial cell envelope responsible for the activation of the host's innate immune system. Variations of the LPS structure utilized by Gram-negative bacteria promote survival by providing resistance to components of the innate immune system and preventing recognition by TLR4. This review summarizes studies of the biosynthesis of Yersinia pseudotuberculosis complex LPSs, and the roles of their structural components in molecular mechanisms of yersiniae pathogenesis and immunogenesis.