A rationally designed peptoid for the selective chelation of Zn<sup>2+</sup> over Cu<sup>2+</sup>
Pritam Ghosh, Galia Maayan
Abstract
A peptoid trimer incorporating picolyl 2,2′:6′,2′′-terpyridine can selectively bind Zn<sup>2+</sup> ions in the presence of excess Cu<sup>2+</sup> ions and other metal ions, in water and in simulated body fluid (SBF) and can remove Zn<sup>2+</sup> from a natural zinc protein in SBF.
Topics & Concepts
PeptoidChemistryZincChelationTrimerTerpyridineIonMetal ions in aqueous solutionZinc compoundsManganeseInorganic chemistryMetalCopperNuclear chemistryOrganic chemistryPeptideDimerBiochemistryChemical Synthesis and AnalysisMolecular Sensors and Ion DetectionAdvanced biosensing and bioanalysis techniques