Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent
Mincong Su, Xia Huang, Chuanhu Lei, Jian Jin
Abstract
A nickel-catalyzed reductive cross-coupling has been achieved using (hetero)aryl bromides and vinyl acetate as the coupling partners. This mild, applicable method provides a reliable access to a variety of vinyl arenes, heteroarenes, and benzoheterocycles, which should expand the chemical space of precursors to fine chemicals and polymers. Importantly, a sustainable solvent, dimethyl isosorbide, is used, making this protocol more attractive from the point of view of green chemistry.
Topics & Concepts
IsosorbideChemistryArylNickelVinyl acetateSolventCatalysisOrganic chemistryCoupling (piping)Reductive eliminationCombinatorial chemistryPolymerCopolymerMaterials scienceMetallurgyAlkylCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsChemical Synthesis and Reactions