P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality
Athis Arunachalam, Sanju S. Samuel, Arunmani Mani, Janielle P. Maynard, Kelsey Stayer, Eric Dybbro, Subapradha Narayanan, Aalekhya Biswas, Saliha Pathan, Krishnakant G. Soni, Abu Hena Mostafa Kamal, Chandra Shekar R. Ambati, Nagireddy Putluri, Moreshwar S. Desai, Sundararajah Thevananther
Abstract
Our studies provide experimental evidence for P2Y2 purinergic receptor-mediated potentiation of inflammatory liver injury, morbidity, and mortality, in two well-established animal models of inflammatory liver injury. Our findings highlight the potential to target P2Y2 purinergic signaling to attenuate the induction of "cytokine storm" and prevent its deleterious consequences on liver function, systemic amino acid homeostasis, host response to bacterial infection, and sepsis-associated morbidity and mortality.