Ligand-centred redox activation of inert organoiridium anticancer catalysts
Wenying Zhang, Samya Banerjee, G. M. Hughes, Hannah E. Bridgewater, Ji‐Inn Song, Ben G. Breeze, Guy J. Clarkson, James P. C. Coverdale, Carlos Sánchez-Cano, Fortuna Ponte, Emilia Sicilia, Peter J. Sadler
Abstract
complexes, which are catalysts for GSH oxidation. The complexes promoted elevated levels of reactive oxygen species (ROS) in human lung cancer cells. This remarkable ligand-centred activation mechanism coupled to redox reactions adds a new dimension to the design of organoiridium anticancer prodrugs.
Topics & Concepts
RedoxInertLigand (biochemistry)CatalysisChemistryCombinatorial chemistryInorganic chemistryOrganic chemistryBiochemistryReceptorMetal complexes synthesis and propertiesSynthesis and Biological EvaluationSynthesis and Characterization of Heterocyclic Compounds