Stealth Effect of Short Polyoxazolines in Graft Copolymers: Minor Changes of Backbone End Group Determine Liver Cell-Type Specificity
Irina Muljajew, Sophie Huschke, Anuradha Ramoji, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Wanling Foo, Jürgen Popp, Marc Thilo Figge, Christine Weber, Michael Bauer, Ulrich S. Schubert, Adrian T. Press
Abstract
performance. To understand these effects, the end group was additionally modified by the attachment of four methacrylic acid repeating units. Although various micelles appeared similar in dynamic light scattering and cryo-transmission electron microscopy, changes in the micelles were evident from principal component analysis of the Raman spectra. Whereas an efficient stealth effect was found for micelles formed from polymers with anionically charged or thiol end groups, a hydrophobic end group altered the micelles' structure sufficiently to adapt cell-type specificity and stealth properties in the liver.