Overcoming O–H Insertion to <i>Para</i>-Selective C–H Functionalization of Free Phenols: Rh(II)/Xantphos Catalyzed Geminal Difunctionalization of Diazo Compounds
Yang Yang, Bin Lu, Gui-Qing Xu, Xiaoming Wang
Abstract
-selective C-H rather than O-H insertion for the carbenoid intermediate, combined with features of excellent functional group compatibility, high atom and step economy, and ease in further diversification of the products, might render this protocol highly attractive in facile functionalization of unprotected phenols.
Topics & Concepts
GeminalXantphosChemistryCatalysisSurface modificationDiazoIsoindolineCombinatorial chemistryPhenolsMedicinal chemistryOrganic chemistryPalladiumPhysical chemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions