The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier
Joséphine Zangari, Francesco Petrelli, Benoît Maillot, Jean‐Claude Martinou
Abstract
Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC). In this review, we report the latest findings on the physiology of the MPC and we discuss how a dysfunctional MPC can lead to diverse pathologies, including neurodegenerative diseases, metabolic disorders, and cancer.
Topics & Concepts
Citric acid cycleGlycolysisOxidative phosphorylationMitochondrionCytosolBiochemistryPyruvate decarboxylationCell biologyMetabolismPyruvic acidChemistryBiologyEnzymeMitochondrial Function and PathologyCancer, Hypoxia, and MetabolismATP Synthase and ATPases Research