Nongenetic control of receptor signaling dynamics using a DNA-based optochemical tool
Ryosuke Ueki, S. HAYASHI, Masaya Tsunoda, Momoko Akiyama, Hanrui Liu, Tasuku Ueno, Yasuteru Urano, Shinsuke Sando
Abstract
Optochemical tools that can modulate the activity of the target protein provide an opportunity for studying and regulating the related biological processes. Here we present a DNA-based nongenetic optochemical tool that can control the dynamics of growth factor signaling. This photo-caged mimicry of growth factor can be a promising tool for elucidating a linkage between the dynamics of signaling and the resulting biological outcomes, as well as for manipulating cellular functions and the fate of living cells.
Topics & Concepts
DNADynamics (music)Computational biologyCellDNA synthesisCell biologyControl (management)ChemistryBiologyComputer scienceBiochemistryArtificial intelligencePsychologyPedagogyPhotochromic and Fluorescence ChemistryReceptor Mechanisms and SignalingCircadian rhythm and melatonin